Fourty three patients known to have cervical intraepithelial neoplasia were assigned to Papanicolaou smear in five different ways, I, e, A) cotton tipped wood applicator at the posterior vagina fornix and the ectocervix, B)cotton tipped wood
applicator
at the ectocervix and the endocervical canal, C) Cytobrush at the endocervical canal, D) Cervexbrush and E) Cyto-spatula. At the completion of cytologic study, all the subjects were done colposcopically directed biopsy and/or ECC. To evaluate the
false
negative rates of the cytologic test, cervical cone biopsy or hysterectomy was performed on all the patient. The false negative rates were 53.5% in B), 14.0% in C), 18.6% in D), 25.6% in E) and statistical differences occured between each group.
It
was
also found that bleedings were most frequently endountered in E) and the encocervical cells were most frequently appeared in C). With these results, it can be stated that the rate of negative encocervical cells in the smear were correlated with
the
false negative rates of cervical cytology.
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